Mitochondrial Permeability Transition Pore

A multiprotein inner mitochondrial complex which opens only under certain pathological conditions (e.g., OXIDATIVE STRESS) uncoupling the membrane leading to APOPTOSIS and MITOCHONDRIAL TRANSMEMBRANE PERMEABILITY-DRIVEN NECROSIS particularly in CARDIOMYOCYTES during MYOCARDIAL REPERFUSION INJURY.

Also Known As:

Mitochondrial Megachannel; Mitochondrial Permeability Transition Pore (mPTP); mPTP Protein

Macromolecular Substances: 97
- Multiprotein Complexes: 128
  - Mitochondrial Permeability Transition Pore: 818
Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Membrane Proteins: 10262
    - Membrane Transport Proteins: 606
      - Mitochondrial Membrane Transport Proteins: 10
        Mitochondrial Permeability Transition Pore: 818
  - Mitochondrial Proteins: 1859
    - Mitochondrial Membrane Transport Proteins: 10
      - Mitochondrial Permeability Transition Pore: 818

Sunita Jaitley Selected Research

Sunita Jaitley Research Topics

Disease

Drug/Important Bio-Agent (IBA)